Purification Services
Expert contract purification — from small-scale chromatographic polishing to multi-gram preparative isolation. We recover and refine your compound to the purity your project demands.
Purification Techniques
We select and combine methods based on compound properties, scale requirements, and target purity specifications.
🧫 Preparative HPLC
Reverse-phase & normal-phase for high-resolution separation of closely eluting impurities. Suitable for polar, non-polar, and chiral compounds.
🌊 Flash Chromatography
Automated flash purification on silica or reverse-phase. Cost-effective for crude reaction mixtures at gram to multi-gram scale.
❄️ Recrystallisation
Solvent & anti-solvent techniques for scalable, cost-effective upgrade of crystalline solids. Preferred final polishing for API intermediates.
🧲 Ion Exchange
Cation/anion exchange resins for removal of ionic impurities, inorganic salts, and residual metals from pharmaceutical intermediates.
🌀 Size Exclusion
Molecular-size-based separation for removal of oligomers, polymers, or high-MW byproducts from small-molecule compounds.
♨️ Distillation & Extraction
Vacuum/fractional distillation & liquid-liquid extraction with pH-controlled phase separation for multi-component mixtures.
Applications & Achievable Purities
| Compound Type | Starting Purity | Achieved Purity | Recommended Technique | Typical Scale |
|---|---|---|---|---|
| API crude (non-chiral) | 85 – 95% | ≥ 99.0% | Flash + Recrystallisation | g – kg |
| Chiral API / enantiomer | 80 – 90% ee | ≥ 99% ee | Chiral Prep-HPLC | mg – g |
| Pharm. impurity standard | 70 – 90% | ≥ 98.0% | Preparative HPLC | mg – g |
| Synthesis intermediate | 75 – 92% | ≥ 97.0% | Flash chromatography | g – kg |
| Residual metal removal | > 500 ppm | < 5 ppm | Ion Exchange / Scavenger | g – kg |
Our Workflow
A straightforward process designed to minimise turnaround time and maximise recovery.
1. Sample Submission
Send crude material (min 50 mg) with HPLC trace, structure, and purity target.
2. Analytical Assessment
HPLC/TLC/NMR profiling to select the optimal purification strategy.
3. Method Scouting
Small-scale trials confirm separation before full-scale commitment.
4. Purification Run
Full-scale run with fraction collection and real-time UV monitoring.
5. QC & Characterisation
Verified by analytical HPLC, NMR, MS. Solvent content checked by NMR/KF.
6. Delivery
Shipped with full CoA, analytical data pack, and recovery yield report.
Request Purification Service
Submit your sample details and target purity. Our team will get back to you within 2 business days.