Pharma & Specialty Chemical Standards

6α-Methylprednisolone, IUPAC name (6α)-6-methyl-11β,17α,21-trihydroxy-9-fluoro-1,4-pregnadien-3,20-dione (C22H28O5, molecular weight 372.46 g/mol), is a synthetic glucocorticoid steroid. Its structure features a methyl group at C6α, fluorine at C9, and hydroxyl groups at C11β and C17α, enhancing metabolic stability. It is a white, crystalline solid with high lipophilicity, enabling cell membrane permeability. Therapeutically, it is employed for its potent anti-inflammatory and immunosuppressive effects in autoimmune and inflammatory conditions. Mechanistically, it binds glucocorticoid receptors, modulating gene transcription to suppress pro-inflammatory pathways, including phospholipase A2 inhibition and cytokine suppression.