Pharma & Specialty Chemical Standards

Abacavir, a nucleoside reverse transcriptase inhibitor (NRTI), is a key antiretroviral agent with the IUPAC name (1S,2R,5S)-2-amino-1-(2-hydroxyethoxy)-5-methylpyrrolidin-3-ol. Its molecular formula is C9H17N3O3, molecular weight 215.25 g/mol. Structurally, it features a pyrrolidin-3-ol core with a hydroxyethylamino substituent and a methyl group. Abacavir is employed in HIV-1 treatment, demonstrating solubility in water and DMSO, with a pKa of ~5.5. It functions as a deoxyguanosine analog, competitively inhibiting HIV reverse transcriptase and inducing DNA chain termination during viral replication.