Pharma & Specialty Chemical Standards

Acesulfame, IUPAC name 6-(Methylsulfonyl)-1,2,3-oxathiazine-4(5H)-one 1,1-dioxide, is a synthetic sulfonamide derivative with molecular formula C₄H₇KO₃S and molecular weight 180.18 g/mol. Structurally, it features a cyclic sulfamate core with a methoxy group, conferring high thermal stability and water solubility. Classified as an artificial sweetener, it exhibits intense sweetness (200× sucrose) without caloric contribution. Key physicochemical properties include non-hygroscopicity and pH stability. Mechanistically, it binds to sweet taste receptors (T1R2/T1R3 heterodimers) without metabolic activation, eliciting sweet taste perception. It is widely used in low-calorie foods and beverages as a bulk-free sweetener.