Pharma & Specialty Chemical Standards

Albendazole, IUPAC name 5-(propylthio)-1H-benzimidazole-2-acetamide, is a benzimidazole derivative with molecular formula C12H11N3O2S (molecular weight 261.3 g/mol). Its structure features a benzimidazole core linked to a propylthio group and acetamide moiety. Therapeutically, it targets parasitic infections by binding to tubulin, inhibiting microtubule polymerization and disrupting cellular functions. It is a white to off-white crystalline solid, sparingly soluble in water (pKa ~4.5) but soluble in organic solvents. Its lipophilicity facilitates tissue penetration. Mechanistically, it acts as a competitive inhibitor of tubulin, inducing metabolic arrest in helminths.