Pharma & Specialty Chemical Standards

Allopregnanolone, IUPAC name 3α-Hydroxy-5β-pregnan-20-one, is a neurosteroid with molecular formula C21H32O2 and molecular weight 312.47 g/mol. Structurally, it belongs to the pregnane class, featuring a 3α-hydroxy group and a 5β-reduced ring. Therapeutically, it modulates GABA-A receptors, exhibiting anxiolytic, anticonvulsant, and antidepressant properties. It is a white crystalline solid with low water solubility and high lipid solubility. Its mechanism involves positive allosteric modulation of GABA-A receptors, enhancing inhibitory neurotransmission. Key physicochemical properties include a melting point of ~140°C and stability under neutral conditions.