Pharma & Specialty Chemical Standards

Amphotericin B, a polyene macrolide antifungal agent, has the IUPAC name Amphotericin B, molecular formula C47H75NO17, and molecular weight of approximately 924.1 g/mol. Structurally, it features a large macrocyclic lactone ring with conjugated double bonds and multiple hydroxyl groups, conferring amphipathic properties. Therapeutically, it targets systemic fungal infections (e.g., candidiasis, aspergillosis) and protozoal diseases (e.g., leishmaniasis). Mechanistically, it binds ergosterol in fungal membranes, forming pores that disrupt ion homeostasis. It is a yellow, amorphous powder with low water solubility but higher solubility in organic solvents, exhibiting polycyclic structures with hydrogen-bonding capabilities due to its hydroxyl groups.