Pharma & Specialty Chemical Standards

Aripiprazole, IUPAC name 7-[4-(4-fluorophenyl)-4-hydroxy-1-piperidinyl]-3-methyl-3,4-dihydro-2(1H)-quinolinone (C23H27FN4O2, molecular weight 409.49 g/mol), is a substituted quinolinone derivative with a piperidine ring and fluorophenyl substituent. It functions as a dopamine D2 and serotonin 5-HT1A partial agonist and 5-HT2A antagonist, modulating neurotransmission. Therapeutically, it treats schizophrenia and bipolar disorder. Physicochemically, it is a white to off-white solid with limited water solubility (pKa ~8.5) and lipophilicity. Its mechanism involves balanced receptor activation, distinguishing it from classical antipsychotics by avoiding full antagonism, thereby reducing extrapyramidal side effects.