Pharma & Specialty Chemical Standards

Atazanavir, IUPAC name (2S,3S,4S,5R,6R)-2-amino-6-[(2S,3R,4R,5S,6E)-4-(2-aminoethyl)-3-hydroxy-5-methylhex-6-en-2-yl]-3,4-dihydroxy-5-(hydroxymethyl)oxan-3-yl] 2-[(2R)-2-[(2S)-2-amino-3-(hydroxymethyl)propanamido]propanamido]pentanoate, is a protease inhibitor with molecular formula C38H48N6O5S and molecular weight 700.38 g/mol. It features a bicyclic scaffold with a sulfonamide moiety and hydroxyl groups. Therapeutically used for HIV-1 treatment, it exhibits low aqueous solubility and is a prodrug requiring hepatic activation. Its mechanism involves competitive inhibition of HIV protease, blocking viral polyprotein cleavage and maturation. Key physicochemical properties include yellow crystalline solid form and metabolic stability via CYP3A4.