Pharma & Specialty Chemical Standards

Azelnidipine, a dihydropyridine calcium channel blocker, is chemically known as (±)-3-ethyl-5-methyl-2-(2-aminoethyl)-4-(2-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid. Its molecular formula is C₁₈H₂₀ClN₃O₄, with a molecular weight of 377.82 g/mol. Structurally, it features a dihydropyridine core substituted with ethyl, methyl, and 2-chlorophenyl groups, conferring vascular selectivity. Therapeutically, it is indicated for hypertension and angina. Physicochemically, it exhibits lipophilicity and weak basicity, enhancing membrane permeability. Azelnidipine inhibits L-type voltage-dependent calcium channels in vascular smooth muscle and cardiac myocytes, reducing intracellular calcium influx, thereby inducing vasodilation and decreasing peripheral resistance. Its prolonged half-life supports once-daily dosing.