Pharma & Specialty Chemical Standards

Bazedoxifene, IUPAC name (Z)-6-fluoro-2-((4-hydroxyphenyl)imino)-4-methoxy-3-methyl-1,4-dihydroquinoline-3-carboxylic acid, is a selective estrogen receptor modulator (SERM) with molecular formula C18H14FNO3 and molecular weight 311.31 g/mol. Structurally, it features a quinoline core substituted with fluoro, methoxy, and hydroxy groups. Therapeutically, it is used in postmenopausal women for osteoporosis and menopausal symptoms. Its mechanism involves tissue-selective estrogen receptor agonism/antagonism, modulating gene expression and bone resorption. Key physicochemical properties include low water solubility and high lipophilicity, facilitating oral bioavailability. The compound exhibits pH-dependent stability and undergoes hepatic metabolism, primarily via CYP3A4, with excretion via feces and urine.