Pharma & Specialty Chemical Standards

Betamethasone, IUPAC name (11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione), is a synthetic glucocorticoid with molecular formula C₂₂H₂₉FO₅ and molecular weight 392.46 g/mol. Structurally, it features a fluorinated 9α-methyl group and 17α-hydroxyl group, enhancing its anti-inflammatory potency. It belongs to the corticosteroid class, characterized by a pregnane backbone with multiple hydroxyl and ketone functionalities. Therapeutically, it is used for inflammatory, autoimmune, and dermatological conditions. Its lipophilic nature facilitates cell membrane permeability, while high water solubility aids systemic distribution. Mechanistically, it binds glucocorticoid receptors, modulating gene transcription to suppress pro-inflammatory cytokines and immune responses.