Pharma & Specialty Chemical Standards

Blonanserin (IUPAC: 4-(4-(2-methoxyphenyl)piperazin-1-ylmethyl)benzene-1,2-diol) is a piperazine-derived atypical antipsychotic with molecular formula C19H23NO3 (M.W. 313.4 g/mol). Structurally, it features a substituted benzene ring linked to a piperazine moiety and a methoxyphenyl group, conferring lipophilicity (logP ~2.5) and moderate water solubility. Therapeutically, it treats schizophrenia via antagonism of serotonin 5-HT2A and dopamine D2 receptors, modulating neurotransmission. Its mechanism involves G-protein coupled receptor inhibition, with high affinity for 5-HT2A (Ki ~1.5 nM) and D2 (Ki ~10 nM) receptors. The compound is a white crystalline solid, stable under standard conditions, and exhibits optimal bioavailability via oral administration due to its pH-dependent solubility profile.