Pharma & Specialty Chemical Standards

Brexpiprazole, IUPAC name 1-[(4-fluorophenyl)methyl]-4-(2-pyrimidinyl)piperazine, is a piperazine-derived atypical antipsychotic with molecular formula C17H17FN4O and molecular weight 312.35 g/mol. It features a piperazine ring linked to a pyrimidine and fluorophenyl moiety, conferring lipophilicity and metabolic stability. Therapeutically used for schizophrenia and major depressive disorder, it exhibits partial agonism at dopamine D2 and serotonin 5-HT1A receptors, with antagonism at 5-HT2A receptors. It is a white to off-white solid, slightly soluble in water, and metabolized via CYP3A4/2D6. Its mechanism involves modulating monoaminergic neurotransmission, balancing dopaminergic and serotonergic pathways.