Pharma & Specialty Chemical Standards

Bumadizon, IUPAC name 2-(4-benzoyl-1-piperazinyl)-2-oxoethyl 4-methylbenzenesulfonate (C18H20N2O4S, molecular weight 368.43 g/mol), is a sulfonamide derivative with a piperazine core. Structurally, it features a benzoyl group linked to a piperazine ring and a methylbenzenesulfonate moiety. Classified as an antipsychotic and antihypertensive agent, it exhibits moderate water solubility and lipophilicity. Therapeutically, it modulates central nervous system dopamine receptors, primarily acting as a dopamine D2 receptor antagonist. Its mechanism involves inhibiting dopamine signaling, reducing psychotic symptoms and peripheral vasoconstriction. Key physicochemical properties include a melting point of ~180°C and stability under neutral pH conditions.