Pharma & Specialty Chemical Standards

Carprofen, IUPAC name 4-chloro-3-methyl-5-(2-propyl)phenylacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with molecular formula C₁₄H₁₅ClO₂ and molecular weight 250.68 g/mol. Structurally, it belongs to the propionic acid derivatives class, featuring a substituted phenylacetic acid core with a chloro, methyl, and propyl substituent. It exhibits anti-inflammatory, analgesic, and antipyretic properties, primarily used in veterinary and human medicine for arthritis and musculoskeletal pain. Carprofen is a white crystalline solid with low water solubility and high lipophilicity. Its mechanism involves reversible inhibition of cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. Key physicochemical properties include pKa ~4.5 and melting point ~140°C.