Pharma & Specialty Chemical Standards

Chloroquine, with the IUPAC name 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline, has the molecular formula C₁₈H₂₆ClN₃ and a molecular weight of 319.89 g/mol. It belongs to the 4-aminoquinoline class, characterized by a quinoline ring substituted with a chloro group at position 7 and a diethylaminoethyl side chain. Therapeutically, it is used as an antimalarial and in autoimmune disorders. Its physicochemical properties include weak basicity, water solubility, and cationic amphiphilicity. Mechanistically, it accumulates in acidic organelles, inhibiting heme polymerization into hemozoin in Plasmodium, and modulates immune responses by interfering with endosomal pH and antigen processing.