Pharma & Specialty Chemical Standards

Chlorphenamine, also known as chlorpheniramine, is a first-generation H1 receptor antagonist. Its IUPAC name is (±)-2-phenyl-2-(1-piperidinylmethyl)propane-1-ol, with molecular formula C16H19ClN2 and molecular weight 274.78 g/mol. Classified as a piperidine derivative, it features a piperidine ring connected to a phenethylamine backbone. Therapeutically, it treats allergic reactions, urticaria, and pruritus. It is a lipophilic, white crystalline solid with a pKa of ~9.5. Mechanism of action involves competitive inhibition of histamine at peripheral H1 receptors, blocking histamine-mediated effects.