Pharma & Specialty Chemical Standards

Clozapine, an atypical antipsychotic, is chemically 2-chloro-10H-phenothiazine-10-acetamide (C18H17ClN2S, 328.45 g/mol). It features a phenothiazine core with a chloro substituent and an acetamide side chain. Clinically used for treatment-resistant schizophrenia, it exhibits low water solubility and a pKa of ~7.8. Its mechanism involves antagonism of dopamine D1-D4, serotonin 5-HT2A/2C, muscarinic, and histamine receptors, offering a broader receptor profile than typical antipsychotics.