Pharma & Specialty Chemical Standards

Colchicine, IUPAC name (1S,2R,4R,5S,6R,7R,8S,9R)-9-acetyl-6-(hydroxymethyl)-4,5-dihydroxy-2-(hydroxymethyl)-1,7-dimethyl-1,2,3,4,5,6,7,8,9,10-decahydro-1H-isoquinoline-3-one, is a C22H25NO6 isoquinoline alkaloid with a molecular weight of 399.44 g/mol. It features a tetracyclic ring system with a sulfide bridge and hydroxyl groups. Clinically used for gout and familial Mediterranean fever, colchicine exhibits low water solubility and high lipophilicity. Its mechanism involves binding to tubulin, inhibiting microtubule polymerization, thereby disrupting mitotic spindle formation and reducing inflammation.