Pharma & Specialty Chemical Standards

Dabigatran, a direct thrombin inhibitor, is chemically designated as 2-propyl-1-[(5R,6S)-5,6-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-1,3-thiazolidine-4-carboxylate (C15H22N2O6S, molecular weight 358.38 g/mol). It belongs to the thiazolidine class, characterized by a tetrahydrofuran ring with multiple hydroxyl groups and a carboxylate. Therapeutically, it is employed for stroke prevention in atrial fibrillation and treatment of deep vein thrombosis/pulmonary embolism. Dabigatran exhibits zwitterionic character, low aqueous solubility, and high plasma protein binding. Its mechanism involves reversible, competitive inhibition of thrombin, blocking fibrinogen cleavage and platelet activation.