Pharma & Specialty Chemical Standards

Darunavir, a potent HIV-1 protease inhibitor, is chemically designated as (2S)-3-methyl-2-[(2R)-2-methyl-1-oxo-3-phenylpropan-2-ylamino]butanoic acid, with molecular formula C₁₇H₂₀N₃O₅S and molecular weight 378.43 g/mol. It belongs to the dipeptide-derived class of antiretrovirals, featuring a sulfonamide moiety and a hydrophobic phenyl ring. Therapeutically, it is employed in combination regimens for HIV-1 treatment. Darunavir exhibits high oral bioavailability, low plasma protein binding, and metabolic stability. Its mechanism involves irreversible inhibition of viral protease, blocking cleavage of gag-pol polyproteins, thereby preventing virion maturation. Key physicochemical properties include a pKa of ~4.5 and moderate lipophilicity.