Pharma & Specialty Chemical Standards

Deflazacort (IUPAC: 9-fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; molecular formula C22H29FO5, molecular weight 404.46 g/mol) is a synthetic glucocorticoid steroid. Structurally, it features a pregnane backbone with a 9-fluoro substituent, 11β-hydroxyl, and 17α-hydroxyl groups, enhancing anti-inflammatory potency. Therapeutically, it treats inflammatory and autoimmune disorders. Physicochemically, it is a white crystalline solid with low water solubility and high lipid solubility. Mechanism of action involves binding to cytoplasmic glucocorticoid receptors, translocating to the nucleus, and modulating gene transcription to suppress pro-inflammatory cytokines and stabilize lysosomal membranes.