Pharma & Specialty Chemical Standards

Dehydroindapamide, IUPAC name 6-chloro-3-oxo-2,3-dihydro-1H-indene-5-sulfonamide, is a thiazide-like diuretic with molecular formula C12H8ClN3O3S and molecular weight 309.58 g/mol. Structurally, it features an indane ring fused with a sulfonamide moiety and a chloro substituent. Its therapeutic applications include hypertension and edema management. Key physicochemical properties include moderate water solubility, pKa ~4.5, and lipophilicity. Mechanism of action involves inhibition of the Na+/K+/2Cl− cotransporter in the distal convoluted tubule, enhancing sodium and water excretion. The compound exhibits structural rigidity due to aromatic conjugation, contributing to its diuretic efficacy.