Pharma & Specialty Chemical Standards

Deschloroclozapine (IUPAC: 11-chloro-5H-dibenzo[b,e][1,4]diazepin-5-one) is a dibenzodiazepine derivative with molecular formula C₁₈H₁₆ClN₃ (MW: 313.8 g/mol). Structurally, it features a fused benzodiazepine core with a chloro substituent at position 11. Therapeutically, it acts as an antipsychotic, primarily targeting dopamine D2 and serotonin 5-HT2A receptors. Its high lipophilicity (logP ~3.5) and low aqueous solubility influence its pharmacokinetics. Mechanistically, it functions as a receptor antagonist, modulating neurotransmission in schizophrenia. Key physicochemical properties include a melting point of ~180°C and UV absorption maxima at 280 nm.