Pharma & Specialty Chemical Standards

Desloratadine, (8-chloro-6,11-dihydro-11-(4-piperidin-1-ylbutyl)-5H-benzo[c]cyclohepten-5-one), is a second-generation antihistamine with molecular formula C21H25ClN2O and molecular weight 356.88 g/mol. It belongs to the piperidine class, featuring a piperidine ring linked via a butyl chain to a chlorinated cycloheptadiene core. Therapeutically, it treats allergic rhinitis and urticaria by selectively antagonizing peripheral H1 receptors. Its lipophilic nature (logP ~3.5) and low water solubility enhance oral bioavailability. Metabolized hepatically via CYP3A4, it exhibits minimal central nervous system penetration due to its high receptor affinity and efflux transporter interactions, resulting in reduced sedation compared to first-generation antihistamines.