Pharma & Specialty Chemical Standards

Dexpanthenol, the IUPAC name 3-hydroxy-N-(2,4,5-trihydroxy-3-(hydroxymethyl)oxolan-2-yl)propanamide, is a pro-vitamin B5 derivative with molecular formula C8H15NO5 and molecular weight 205.24 g/mol. Structurally, it features a hydroxylated oxolane ring and an amide-linked hydroxypropane moiety. As a water-soluble, viscous compound with high hygroscopicity, it exhibits a melting point of ~150°C. Therapeutically utilized in dermatological formulations, it functions as a humectant and skin barrier enhancer. Mechanistically, it converts to pantothenic acid in vivo, promoting keratinocyte proliferation and lipid synthesis. Its stability under physiological conditions and non-irritant profile enhance its efficacy in topical applications.