Pharma & Specialty Chemical Standards

Doxycycline, a semisynthetic tetracycline antibiotic, has the IUPAC name 4-Dimethylamino-4-(2-(2,6-dichlorophenyl)ethenyl)-1,4,4a,5,5a,6,12,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacene-carboxamide. Its molecular formula is C22H24N2O8Cl2, with a molecular weight of 505.34 g/mol. Structurally, it features a naphthacene core with multiple hydroxyl and ketone groups, enhancing its stability and broad-spectrum activity. It is a lincosamide-class antibiotic, though chemically distinct from lincosamides. Therapeutically, it treats bacterial infections via protein synthesis inhibition by binding to the 30S ribosomal subunit. It is a yellow crystalline solid with moderate water solubility and pKa values of 2.3 and 9.9, facilitating absorption and tissue distribution.