Pharma & Specialty Chemical Standards

Duloxetine, with IUPAC name (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine, has molecular formula C18H19NO2S and molecular weight 309.4 g/mol. Classified as a serotonin-norepinephrine reuptake inhibitor (SNRI), its structure features a naphthalene ring, thienyl group, and amine moiety. Therapeutically used for major depressive disorder and generalized anxiety disorder. Physicochemically, it is a white to off-white solid with low water solubility and high lipophilicity. Mechanism of action involves selective inhibition of serotonin and norepinephrine reuptake via presynaptic neuronal transporters, enhancing neurotransmitter availability in synaptic clefts.