Pharma & Specialty Chemical Standards

Elitriptan, IUPAC name 2-(2-furyl)-1H-benzimidazole-7-sulfonamide, has molecular formula C13H13N3O3S and molecular weight 291.33 g/mol. A triptan-class compound, it features a benzimidazole core fused with a furan ring and a sulfonamide group. Therapeutically, it treats acute migraines by selectively activating 5-HT1B/1D receptors, inducing vasoconstriction and inhibiting neurogenic inflammation. It is a white to off-white solid with low water solubility (≈0.5 mg/mL) and a LogP of 1.5. Its mechanism involves central and peripheral receptor activation, reducing cranial vasodilation and neuropeptide release.