Pharma & Specialty Chemical Standards

Enzalutamide (IUPAC: 2-(5-(4-cyano-1H-imidazol-1-yl)pentyl)-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; molecular formula C₁₇H₁₉N₅O₄S₂, molecular weight 417.5 g/mol) is a nonsteroidal androgen receptor antagonist. Structurally, it features a benzothiadiazine core linked to an imidazole ring and a terminal cyano group. It is therapeutically employed in castration-resistant prostate cancer. Physicochemically, it is a white to off-white solid with low water solubility but high solubility in DMSO. Its mechanism involves competitive androgen receptor binding, inhibiting nuclear translocation and transcriptional activity, thereby suppressing tumor growth.