Pharma & Specialty Chemical Standards

Eposartan, IUPAC name 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-indole-5-carboxylic acid, is an angiotensin II receptor blocker (ARB) with molecular formula C23H20N6O2 and molecular weight 412.46 g/mol. Structurally, it features an indole core linked to a biphenyl-tetrazole moiety, conferring high lipophilicity and AT1 receptor selectivity. Therapeutically, it is used for hypertension and heart failure. Key physicochemical properties include moderate water solubility and high plasma protein binding. Its mechanism involves competitive inhibition of angiotensin II at AT1 receptors, reducing vasoconstriction and aldosterone secretion.