Pharma & Specialty Chemical Standards

Fingolimod, IUPAC name 2-amino-4-phenylbutylphosphonic acid, is a sphingosine-1-phosphate (S1P) receptor modulator with molecular formula C19H31NO3P (molecular weight 363.43 g/mol). Structurally, it features a sphingoid base with a phosphorylcholine head group, exhibiting amphiphilic characteristics. Therapeutically, it is indicated for relapsing-remitting multiple sclerosis. Physicochemically, it is a white solid with limited water solubility (log P ~2.5) and a pKa of ~6.5. Mechanistically, Fingolimod acts as a functional antagonist of S1P1/3/4/5 receptors, sequestering lymphocytes in lymph nodes and reducing central nervous system inflammation via altered lymphocyte trafficking.