Pharma & Specialty Chemical Standards

Fingolimod, (2S,3R,4R,5S,6R)-2-((2R,3S,4R,5R)-5-(4-((2R,3R,4R,5S,6R)-4-amino-2,3,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)phenoxy)pentyl)amino)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl) methanol, is a phosphorylated sphingosine analog with molecular formula C21H35NO7P (molecular weight 447.48 g/mol). It functions as a functional antagonist of sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, S1P5), sequestering lymphocytes in lymph nodes and reducing central nervous system infiltration. Therapeutically, it is indicated for relapsing multiple sclerosis. Key physicochemical properties include a hydrophilic phosphate group and a hydrophobic sphingosine backbone, enhancing blood-brain barrier permeability. Its mechanism involves receptor-mediated lymphocyte retention, modulating autoimmune responses.