Pharma & Specialty Chemical Standards

Flupirtin, IUPAC name 5-fluoro-2-pyridinecarboxylic acid 4-methylpiperazine, is a pyridinecarboxylic acid derivative with molecular formula C₁₁H₁₂FN₃O₂ and molecular weight 237.18 g/mol. It features a pyridine ring substituted with a fluoro group and a piperazine moiety. Therapeutically, it functions as an analgesic and antipyretic. Physicochemically, it is a white crystalline solid with moderate water solubility and a pKa of ~4.5. Its mechanism involves non-selective inhibition of cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. Key structural characteristics include hydrogen bonding and aromaticity, contributing to its pharmacokinetic profile and metabolic stability.