15 keto latanoprost

15-Keto latanoprost is an oxidized derivative of latanoprost, featuring a ketone group at the C15 position in place of the parent compound's hydroxyl moiety. This structural modification introduces a carbonyl functionality within the cyclopentyl ring, altering the molecule's polarity and hydrogen-bonding capacity. The conjugated diene system and ester linkage remain intact, preserving core prostaglandin-like architecture. As a degradation byproduct formed via oxidative pathways, it serves as an HPLC reference standard for quantifying oxidative impurities in latanoprost drug substances.