15 keto travoprost

15-Keto travoprost is a structurally modified prostaglandin F2α derivative featuring a ketone functional group at the 15β-position of the cyclopentyl ring, substituting the native hydroxyl moiety. This oxidation product retains the fluorinated pentyl side chain and γ-lactone core characteristic of travoprost, with a trifluoromethylphenyl ester linkage. The compound arises as a synthetic byproduct during API manufacturing or via oxidative degradation pathways. Its distinct carbonyl functionality alters intermolecular interactions, necessitating its quantification as a critical impurity in quality control. Analytically, it serves as a reference standard for HPLC-based impurity profiling in travoprost formulations.