ABC00429NZ

17-Dehydro-21-hydroxy hydro cortosone

17-Dehydro-21-hydroxy hydro cortosone is a corticosteroid derivative featuring a cyclopentane-perhydrophenanthrene core with a 17ฮฑ-hydroxy group, 21ฮฒ-hydroxy functionality, and a ฮ”โด (17-dehydro) double bond. It retains the 11ฮฒ-hydroxy and 12ฮฑ-keto groups characteristic of hydrocortisone but lacks the 20ฮฑ-hydroxy group present in the parent Cortosone. The compound serves as a critical process-related impurity in Cortosone synthesis, arising from selective oxidation at C21 and dehydrogenation at C17 during multi-step steroid transformations. This impurity is utilized as an HPLC reference standard for quantitative impurity profiling in Cortosone bulk drug substance analysis.

On Request
Molecular Formula C21H30O6
Molecular Weight 378.5000
CAS Number 68473-77-8 โœ“ Verified
PubChem CID 68135943 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Cortosone
Lead Time On Request
IUPAC Name (8S,9S,10R,11S,13S,14S,17R)-17-(2,2-dihydroxyacetyl)-11,17-dihydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

๐Ÿ“ Synonyms

68473-77-8 (8S,9S,10R,11S,13S,14S,17R)-17-(2,2-dihydroxyacetyl)-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3(2H)-one (8S,9S,10R,11S,13S,14S,17R)-17-(2,2-dihydroxyacetyl)-11,17-dihydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one RefChem:405505 891-975-9 17,21-Dihydroxy-corticosterone 21-hydroxycortisol Hydrocortisone Impurity 21 SCHEMBL11814284 Pregn-4-ene-3,20-dione, 11,17,21,21-tetrahydroxy-, (11?)- (9CI); Corticosterone, 17,21-dihydroxy- (5CI); 11?,17?,21,21-Tetrahydroxypregn-4-ene-3,20-dione

๐Ÿ”ฌ Chemical Identifiers

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)C(O)O)O)C)O
InChI=1S/C21H30O6/c1-19-7-5-12(22)9-11(19)3-4-13-14-6-8-21(27,17(24)18(25)26)20(14,2)10-15(23)16(13)19/h9,13-16,18,23,25-27H,3-8,10H2,1-2H3/t13-,14-,15-,16+,19-,20-,21-/m0/s1
AIPUDODNHSFRNT-HRUPCHJUSA-N

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