4-Hydroxy Aceclofenac

4-Hydroxy Aceclofenac is a chlorinated phenolic acetamide derivative featuring a hydroxyl group at the 4-position of the acetophenone moiety, adjacent to the carboxylic acid functionality. Its structure incorporates two para-chloro substituents on the benzene ring and an acetoxy group at the α-position relative to the amide linkage. This compound arises as a specific oxidation byproduct during Aceclofenac synthesis or degradation under oxidative conditions, resulting from hydroxylation of the aromatic ring. It serves as a critical HPLC reference standard for quantifying oxidative impurity profiles in Aceclofenac formulations.