4_-Hydroxy Flurbiprofen

4'-Hydroxy Flurbiprofen is a fluorinated aromatic carboxylic acid derivative featuring a hydroxyl substitution at the para position of the fluorobenzene ring relative to the parent Flurbiprofen. This metabolite incorporates a 2-propylphenyl moiety linked to a 4-fluoro-3-hydroxybenzoic acid scaffold, introducing a polar hydroxyl group that enhances aqueous solubility compared to the parent compound. The hydroxylation at C4' of the fluorinated ring disrupts the conjugation pattern, altering electronic properties and metabolic stability. Synthetically accessible via selective oxidation of the fluoro precursor, it serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in Flurbiprofen formulations.