4-Hydroxy Propanolol Sulphate

4-Hydroxy Propanolol Sulphate is a benzylamine derivative featuring a 4-hydroxy substituent on the aromatic ring and a sulfate ester conjugated to the primary hydroxyl group of the parent beta-blocker Propanolol. This impurity arises via oxidative hydroxylation at the para-position, introducing a meta-cis configuration that disrupts pharmacophore integrity. The molecule contains three stereocenters, including the chiral amine center, and exhibits enhanced polarity due to the sulfate moiety. It serves as a critical HPLC reference standard for quantifying process-related impurities in Propanolol formulations.