ABC00317DH

7,11-Diethyl-10-hydroxycamptothecin

7,11-Diethyl-10-hydroxycamptothecin is a structural derivative of Camptothecin featuring diethyl substitutions at positions 7 and 11, and a hydroxyl group at position 10. The hydroxyl moiety introduces steric hindrance and alters lactone ring stability compared to the parent compound. This impurity arises during synthetic pathways due to selective ethylation and hydroxylation events. It serves as an HPLC reference standard for quantifying process-related impurities in Camptothecin formulations.

On Request
Molecular Formula C24H24N2O5
Molecular Weight 420.5000
CAS Number 947687-01-6 ✓ Verified
PubChem CID 58965011 ↗
Purity N/A
Product Type API Impurity
Parent Drug Camptothecin
Lead Time On Request
IUPAC Name (19S)-6,10,19-triethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

📝 Synonyms

947687-01-6 7,11-Diethyl-10-hydroxycamptothecin Irinotecan EP Impurity G (S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione XIS57GM9TN 7,11-diethyl-10-hydroxy camptothecin (19S)-6,10,19-triethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione (4S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione (S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,8,11-triethyl-4,9-dihydroxy-, (4S)-

🔬 Chemical Identifiers

CCC1=CC2=C(C=C1O)C(=C3CN4C(=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)C3=N2)CC
InChI=1S/C24H24N2O5/c1-4-12-7-18-14(8-20(12)27)13(5-2)15-10-26-19(21(15)25-18)9-17-16(22(26)28)11-31-23(29)24(17,30)6-3/h7-9,27,30H,4-6,10-11H2,1-3H3/t24-/m0/s1
BQAJEBSARMNUPK-DEOSSOPVSA-N

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