ABC01068CS

7-Epi-10-Desacetyl Paclitaxel

7-Epi-10-Desacetyl Paclitaxel is a taxane-based analog with a 7ฮฒ-hydroxyl configuration and a desacetylated C10 position, differing from Paclitaxel by stereochemical inversion at C7 and loss of the 10ฮฒ-acetyl group. Its core structure retains the 13-ethyl-14ฮฒ-acetoxy taxane skeleton, featuring a side chain amide linked to a 3-phenyl-2-propenyl group. This compound arises as a synthetic byproduct during Paclitaxel production, serving as an HPLC reference standard for quantifying process-related impurities in parent drug formulations.

On Request
Molecular Formula C45H49NO13
Molecular Weight 811.9000
CAS Number 78454-17-8 โœ“ Verified
PubChem CID 14355298 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Paclitaxel
Lead Time On Request
IUPAC Name [(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4-acetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
Other CAS Numbers (also listed on PubChem)
111149-94-1
Official Reference Standards
Std Catalog # Quantity Price
USP 1491354 โ†— 20 mg USD 1467.00

๐Ÿ“ Synonyms

7-Epi-10-deacetyltaxol DTXSID90559294 RefChem:546327 DTXCID60510074 78454-17-8 7-Epi 10-Desacetyl Paclitaxel Paclitaxel EP Impurity H 10-DEACETYL-7-EPIPACLITAXEL 111149-94-1 PF8TD9Q8G5

๐Ÿ”ฌ Chemical Identifiers

CC1=C2[C@H](C(=O)[C@@]3([C@@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O
InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1
TYLVGQKNNUHXIP-DIYBZAJCSA-N

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