9-Piperazino Levofloxacin

9-Piperazino Levofloxacin is a synthetic byproduct generated during Levofloxacin production, featuring a piperazino group appended to the C-9 position of the quinolone scaffold. This substitution introduces a tetrahydro-piperazine ring connected via a methylene bridge, altering the parent drug’s pharmacophore. Retaining the fluorine at C-6, carboxylic acid at C-3, and pyridine-like nitrogen at C-7, the compound exhibits reduced antimicrobial activity. It functions as an HPLC reference standard for monitoring synthetic process impurities in Levofloxacin APIs.