Desdifluoro Dolutegravir

Desdifluoro Dolutegravir is a structural analog of Dolutegravir characterized by the absence of the 3,5-difluoro substituents on the benzamide ring, replaced by hydrogen atoms. It retains the pyrimidine core and cyclopropylmethyl amide moiety, with a hydroxyl group at the 2-position of the benzamide. This impurity arises via partial defluorination during synthetic pathways involving electrophilic fluorination reagents. It functions as a reference standard for HPLC-based quantification of process-related impurities in Dolutegravir active pharmaceutical ingredient batches.