Mirabegron EP impurity F

Mirabegron EP impurity F is a structural analog of Mirabegron, characterized by a 2-(2-aminothiazol-4-yl)acetamide core linked to a 4-(2-hydroxy-2-phenylethyl)phenyl moiety. Unlike the parent drug, Mirabegron EP impurity F features a direct attachment of the 2-hydroxy-2-phenylethyl group to the para-position of the phenyl ring, lacking the intervening 2-aminoethyl bridge present in Mirabegron's side chain. This modification results in the absence of the secondary amine within the phenyl-substituted side chain, distinguishing its linker chemistry. It serves as a crucial reference standard for purity analysis of Mirabegron formulations, particularly in identifying specific synthesis byproducts or degradation pathways.