Open chain Dolutegravir

Open chain Dolutegravir is a structurally related impurity derived from the parent antiretroviral drug Dolutegravir, characterized by the absence of the cyclic dioxolane moiety present in the native compound. Its linear framework retains key pharmacophoric elements, including a 2-cyano-5-trifluoromethylbenzoic acid ester and a cyclopropylmethylamino group, but features an open-chain hydroxyethyl linkage in place of the cyclic ether. This structural modification arises during synthetic pathways or degradation processes, rendering it a critical marker for process optimization. It serves as an HPLC reference standard for quantifying impurity profiles in Dolutegravir formulations.