ABC00136VX

Aciclovir EP Impurity J

Aciclovir EP Impurity J is a structurally related degradation byproduct arising from oxidative cleavage of the acyclic guanine moiety in aciclovir. It features a substituted purine core with an additional oxidized side chain containing a hydroxylated amino group and a carbonyl functionality, distinguishing it from the parent compound. The molecule exhibits enhanced polarity due to the introduction of two additional oxygen atoms and a branched nitrogen-containing side chain. This impurity is specifically employed as an HPLC reference standard for quantifying oxidative degradation pathways in aciclovir formulations under ICH Q1A(R2) guidelines.

On Request
Molecular Formula C14H16N10O4
Molecular Weight 388.3400
CAS Number 166762-90-9 ✓ Verified
PubChem CID 135565046 ↗
Purity N/A
Product Type API Impurity
Parent Drug Aciclovir
Lead Time On Request
IUPAC Name 2-amino-9-[2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethoxymethyl]-1H-purin-6-one

📝 Synonyms

166762-90-9 O-((Guanin-9-yl)methyl) acyclovir O-[(Guanin-9-yl)methyl] Acyclovir UNII-F8EGJ10ICV F8EGJ10ICV Aciclovir impurity J [EP] DTXSID50168184 6H-Purin-6-one, 9,9'-(1,2-ethanediylbis(oxymethylene))bis(2-amino-1,9-dihydro- ACICLOVIR IMPURITY J [WHO-IP] ACICLOVIR IMPURITY J [EP IMPURITY]

🔬 Chemical Identifiers

C1=NC2=C(N1COCCOCN3C=NC4=C3N=C(NC4=O)N)N=C(NC2=O)N
InChI=1S/C14H16N10O4/c15-13-19-9-7(11(25)21-13)17-3-23(9)5-27-1-2-28-6-24-4-18-8-10(24)20-14(16)22-12(8)26/h3-4H,1-2,5-6H2,(H3,15,19,21,25)(H3,16,20,22,26)
QPOMYCBJDYQVEA-UHFFFAOYSA-N

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