Aciclovir Impurity 2

Aciclovir Impurity 2 is a purine-based derivative characterized by a 2-amino-6-(2-hydroxyethoxy)imidazo[5,1-d]-1,3,4-triazin-5(1H)-one core structure. It features a deaminated purine ring and retains the hydroxymethyl ether functionality at position 9. This impurity arises via oxidative degradation of the parent Aciclovir molecule, specifically through cleavage of the glycosidic linkage. It serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in Aciclovir formulations.