ABC00135CZ

Acyclovir ImpI

Acyclovir ImpI is a synthetic byproduct arising from the acyclic nucleoside pathway of aciclovir production. It features a substituted purine core fused to a modified cyclopropane ring, with an additional methylene bridge and a terminal hydroxyl group compared to the parent drug. The molecule contains four amino functionalities, two heterocyclic nitrogen atoms, and a phosphorylated sugar analog moiety. Its structural divergence from aciclovir includes an extra carbonyl group in the side chain, which disrupts the canonical hydrogen-bonding pattern. This impurity serves as an HPLC reference standard for quantifying process-related deviations in aciclovir API batches.

On Request
Molecular Formula C14H16N10O4
Molecular Weight 388.3400
CAS Number 1797832-75-7 ✓ Verified
PubChem CID 135566097 ↗
Purity N/A
Product Type API Impurity
Parent Drug Aciclovir
Lead Time On Request
IUPAC Name 2-amino-9-[2-[(2-amino-6-oxo-1H-purin-7-yl)methoxy]ethoxymethyl]-1H-purin-6-one

📝 Synonyms

1797832-75-7 Acyclovir Impurity I Aciclovir EP Impurity I O-[(Guanin-7-yl)methyl] Acyclovir (>90%) 2-amino-7-((2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)ethoxy)methyl)-1,7-dihydro-6H-purin-6-one 2-AMINO-9-((2-((2-AMINO-6-OXO-1H-PURIN-7(6H)-YL)METHOXY)ETHOXY)METHYL)-1H-PURIN-6(9H)-ONE 2-Amino-9-((2-((2-amino-6-oxo-3,6-dihydro-7H-purin-7-yl)methoxy)ethoxy)methyl)-3,9-dihydro-6H-purin-6-one 2-Amino-7-[[2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethoxy]methyl]-1,7-dihydro-6H-purin-6-one C14H16N10O4 ACICLOVIR IMPURITY I [WHO-IP]

🔬 Chemical Identifiers

C1=NC2=C(N1COCCOCN3C=NC4=C3C(=O)NC(=N4)N)N=C(NC2=O)N
InChI=1S/C14H16N10O4/c15-13-19-9-8(12(26)22-13)23(4-18-9)5-27-1-2-28-6-24-3-17-7-10(24)20-14(16)21-11(7)25/h3-4H,1-2,5-6H2,(H3,15,19,22,26)(H3,16,20,21,25)
ZKDRLENQIACTMV-UHFFFAOYSA-N

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